They're the new "bad boys" of atherosclerosis, not Cholesterol but ...Submitted by Ed Thinking on Mon, 04/08/2013 - 10:55
TMAO & carnitine: Your new words for the day. They're the new "bad boys" of atherosclerosis. Don't miss this HOT new research just published yesterday (4/7/13) by Cleveland Clinic researchers in the Journal Nature Medicine
1. Carnitine typically helps the body transport fatty acids into cells to be used as energy. But researchers at the Cleveland Clinic found that in both humans and mice, certain bacteria in the digestive tract convert carnitine to another metabolite, called TMAO, that promotes atherosclerosis, or a thickening of the arteries.
5. The researchers, led by Stanley Hazen, chief of cellular and molecular medicine at the Cleveland Clinic's Lerner Research Institute, tested the carnitine and TMAO levels of omnivores, vegans and vegetarians, and examined records of 2,595 patients undergoing cardiac evaluations. In patients with high TMAO levels, the more carnitine in their blood, the more likely they were to develop cardiovascular disease, heart attacks, stroke and death.
6. Dr. Hazen speculated that carnitine could be compounding the danger. "Cholesterol is still needed to clog the arteries, but TMAO changes how cholesterol is metabolized—like the dimmer on a light switch," he said. "It may explain why two people can have the same LDL level [a measure of one type of cholesterol], but one develops cardiovascular disease and the other doesn't."
The rest of the article with more links: http://on.fb.me/Zvig7w