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What I've learned from legal marijuana in my state.

Hey guys, this article "3 studies that show cannabis grows brain cells" set me on a writing tangent that I thought I should share.

Everything in this post has been learned by me in the past 3 months while the stores have been open. It takes a scientific outlook on the new things we are learning now that research can be legally conducted.

The endocannabinoid system is a system that acts upon literally every other system in your body. It regulates homeostasis of the bodily functions, in other words, it keeps every system in your body within certain parameters necessary for proper function. When cells get low on fuel, they send signals to the brain telling them the body needs an intake of food. The brain then releases a small amount of anandamide (endocannabinoid), and you literally give yourself the munchies. That happens every time you get hungry.

Phytocannabinoids, phyto meaning from the plant, endo meaning produced inside the body. There are scores of phytocannabinoids found in cannabis that act on your cannabinoid system with every one of them seeming to promote health and healing disease. Right now is one of the most exciting times for this research since the Bush/Clinton crime syndicate no longer has such a death grip on our laws. Families are uprooting their lives to move to Colorado and give this medicine to their children. This is criminal, no person should have to compromise anything in order to use a plant from the ground. Arguments to the contrary are an example of cognitive dissonance.

At the bottom of this post, I will give tips on preparing cannabinoids to be absorbed into the body to gain the benefits. EATING RAW CANNABIS WILL NOT GET YOU HIGH, AND WILL NOT ALLOW FOR MAXIMUM MEDICINAL BENEFITS. As most of the cannabinoids will simply pass through without absorption... It's a waste of weed.

Not much definitive research has been done because of CRIMINALS preventing free people from possessing an herb from God. This cult of statism has caused countless suffering and death by denial of a healing plant. As well as countless addictions and deaths occurring from unnecessary, harmful products produced by the pharmaceutical companies, enriching the Bush/Clinton syndicate.

Here's a look at some of the better known cannabinoids[1]:

THCA: tetrahydrocannbinolic acid. This is the most abundant phytocannabinoid found in cannabis. It is non-psychoactive. The molecule is identical to THC with the exception of a Carboxylic acid (COOH) group attached to it. It appears to hold great promise as an anti-oxidant and it's full medical benefits are still yet to be shown through scientific study. Once inside the body, there is almost zero conversion of THCA into THC, meaning the value of the medicine can be realized without the "high" that users experience.

THC: tetrahydrocannbinol. The famous psychoactive molecule of cannabis. Very little THC is found naturally in the cannabis plant. THC is produced when heat or time causes the COOH group to be knocked off of the THCA molecules. In smoked cannabis, the combustion converts a percentage of THCA into THC, causing the psychoactive effects. In eaten cannabis, cooking causes this. THC has been shown to have many positive effects in killing diseases. THC acts like anandamide as an agonist upon the CB1 receptor found throughout the central and peripheral nervous systems, giving it its psychoactive properties.

CBD: Cannabidiol. CBD is the second most abundant phytocannabinoid found in cannabis. It is the molecule that appears to hold the most medicinal properties found in cannabis. Though considered non-psychoactive, studies have shown CBD to have an antagonist role on the CB1 receptor, meaning it prevents or inhibits THC or anandamide from effecting the neurons carrying the CB1 receptor. Cannabis strains high in CBD such as Charlette's Web are in extreme demand due to the medical benefits of this molecule.

CBN: Cannabinol. CBN is not produced directly by the cannabis plant, but is produced when THC degrades over time. It is identical in structure to THC but with a butyl (4 carbon) chain instead of the pentyl (5 carbon) chain in THC. CBN is considered to be non-psychoactive but does act as an agonist on the CB2 receptor found throughout the peripheral nervous system possibly giving a "body high" some users experience. The CB2 receptor is not found in the central nervous system.

THCV: thetrahydrocannabivarin. Found more in sativa dominate strains, THCV is identical to THC and CBN except it has a propyl (3 carbon) chain instead of the butyl and pentyl chains found in CBN and THC respectively.

CBG: Cannabigerol. CBG is non-psychoactive. But it has been attributed to lowering intra-ocular pressure thereby reducing the harmful effects of glaucoma. Not many studies have focused on the effects of CBG.

CBC: Cannabichromene. Another non-psychoactive cannabinoid. Studies are being done to study anti-viral and anti-inflammatory effects of CBC.

Cannabinoid absorption into the body:

Cannabinoids are hydrophobic, meaning they are repelled by water and will not dissolve in water. It is very difficult to get high from cannabis tea, as the water prevents the cannabinoids from dissolving and absorbing into the bloodstream. However, cannabinoids will dissolve into fatty acids. Adding cream or milk to cannabis tea will greatly increase the absorption rate.

Because cannabinoids dissolve into fatty acids, and fatty acids are readily absorbed into the lymphatic system (the body loves fatty acids, and many of them bypass the bloodstream directly by going into the lymphatic system for faster utilization), this is the best way to make use of your medicine. Heat is a prerequisite to activating the psychoactive effects of cannabis, as raw cannabis will not get you high. If you would like to activate the psychoactive effects of cannabis, you must heat it before ingestion.

What I do is go to the store and get some cannabis oil concentrate (plant matter will work too, but it's harder to know the dose). I then get coconut oil for preparing the medicine (most oils or butters or creams will do, I prefer coconut oil). Most of the time, I prefer to activate the psychoactive effects for relaxation. If not, I'll heat up the coconut oil just enough to make it liquid (80 degrees) so the cannabinoids will dissolve, but I don't get high. To activate the psychoactive effects I'll put the equivalent in cannabis oil of about 100mg of THC into a shot glass full of coconut oil (the proper amount is extremely variable from person to person, know how much you personally can handle. Too much WILL NOT be enjoyable). I'll then place the shot glass in a partially filled pot of water (careful to keep the water out of the shot glass) and let simmer for about 20 minutes. This will decarboxylate the THCA into THC and activate the "high" users experience. After ~20 min of simmering, I will let the shot glass cool. Usually I'll speed up the cooling process by adding a bit of cold water to the simmering water. If you use purely cold water, you may end up cooling the glass too much causing it to crack, ruining the contents inside. Once cool, you have a fully prepared single dose of medicine, take the shot. I like this method because the simmering water guarantees the heat won't get over 212 degrees. Higher heats are not necessary. Plus it reminds me of the movie "Menace to Society." There are better ways to prepare it, but this one works for me and the main principles are communicated in the recipe.

This recipe is only for a single dose, but the ingredients can be extrapolated to make larger amounts. Just make sure you know how much you have in your final product. The stores label THC content, and this label is usually proportional to how much it will effect you. This single dose will last me the entire rest of the day if taken right after work and will be effective in treating my insomnia when I go to bed that night without further medication.

Key points:
-cannabinoids are hydrophobic and will not dissolve in water, nor be efficiently absorbed into the body without fatty acids.

-Raw cannabis will not be psychoactive, to activate the psychoactive effects, heat must be applied.

-liquid fatty acids dissolve the cannabinoids making the readily absorbable inside the gastrointestinal tract.

Pro-tip: Dark Chocolate contains anandamide, the endocannabinoid found in your body. Eating a bar of dark chocolate will add to the pleasurable effects of cannabis. Another neurotransmitter found in dark chocolate is oxytocin, afeel good drug. It also includes phenylalanine, which is an essential amino acid used in dopamine production.

And now you know how to properly prepare your medicine. Happy medication everyone! "The more you know..."

For more about the medical benefits of cannabis, YouTube videos of Dr. Bob Melamede and visit his University of Colorado at Colorado Springs page here: http://www.uccs.edu/~rmelamed/

Also be on the look out for the documentary "Run From the Cure II: Run 2 the Cure" which should be released later this year. Rick Simpson opened my eyes years ago to the corruption suppressing this medicine with his original documentary. See:
http://phoenixtears.ca

Works cited:

[1] http://www.cannlabs.com/the-science/cannabinoids/

PS: I must express my disappointment in the cannabis market in Colorado. The state has instituted such ridiculous taxes and are further trying to regulate it so much it pisses me off. My DP friends can understand this. Prices are 3 times higher than before the legal market. And higher than in other states' black markets. Direct sales taxes are 25%, but because the Feds won't allow the business to deduct legitimate business expenses, the effective tax is probably closer to 60-80%. People are still getting shot and killed in Colorado attempting to sell marijuana on the black market. See: http://www.startribune.com/politics/national/253860141.html. Further, the state is spending millions of dollars on TV ads informing people they can't drive high, as if this is some new phenomenon that wouldn't exist in a black market. These ads make cannabis users out to be a bunch of morons that can't perform the most basic tasks. My post above shatters the conventional image of a pot head in my opinion.

EDIT: To be clear, when I use the term "raw cannabis" I simply mean the plant material all by itself, unheated. If you take raw cannabis, and mix it with oil or some sort of fatty acid base, this is how you unlock the medical benefits. If you then heat that, you unlock the psychoactive effects. HEATING IS NOT NECESSARY FOR MEDICAL BENEFITS. And unheated, prepared cannabis is preferable for people that don't want the "high" associated with use.

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So, basically, what you're saying is...

"EVERYTHING'S BETTER with a bag of weed."

I'm currently reading our own tax dollars being spent on the study of Hemp, albeit from an agricultural POV:

https://www.fas.org/sgp/crs/misc/RL32725.pdf

The utility, alone, will help with a lot of World issues. But definitely, not all.

Edit: To those DP'ers who are not reading the entire article (You know better than that, DP members!), this line is crucial:

"HEATING IS NOT NECESSARY FOR MEDICAL BENEFITS"

If you don't know your rights, you don't have any.

Hey man could you research if this stuf I just bought is catnip?

???

Thanks man.

Don't feed the pandas. Ever.

To the OP

Thanks to the information I got from the good people on this site, my long time buddy with Stage 4 Stomach cancer has started the official Rick Simpson/Phoenix Tears treatment earlier last week. So far so good!

Thank a bunch to the OP for posting this!

Please keep us updated on your friend, Antelmann.

I hope the Rick Simpson oil serves him well and God Bless you for even thinking about the idea.

If you don't know your rights, you don't have any.

Buy this oil in any form

I endorse Tetra Labs 100%

http://tetralabs.com/

Video:
Tetra Labs Pure Gold
https://www.youtube.com/watch?v=iGRS-YG2s9s

The world is my country, all mankind are my brethren, and to do good things is my religion. Thomas Paine, Godfather of the American Revolution

Using Cannabis to help Drug Addicts

Has anyone in these states heard of a program which either uses cannabis directly or allows their patients to use cannabis to treat various substance abuse issues?

From the research I have done, I believe this to be the future of substance abuse treatment.

Gateway out of addiction

Many patients say it helps them wean off substances that actually are addicting, such as opiate pain medications (like oxycodone and hydrocodone), anxiolytics (like benzodiazepines), hard core street drugs (cocaine, methamphetamine, heroin...), alcohol and tobacco, while simultaneously treating some of the physical, emotional and mental symptoms that these substances are being used to treat (pain, anxiety, depression, irritability, insomnia, etc.)

Bad idea

Bad idea

The world is my country, all mankind are my brethren, and to do good things is my religion. Thomas Paine, Godfather of the American Revolution

Would you mind elaborating?

In the field of substance abuse treatment, replacement therapy is quite common. For instance, both Methadone and Suboxone are prescribed medications marketed as the solution to opiod narcotic addiction. Opoid narcotics vary from pain pills like Lortab, Oxycontin, and Morphine to the illicit concotion, heroin.

Rather than the much touted theory that cannabis is a "gateway drug", it is in fact being found to be an "exit drug". This interesting study from Canada, which has a medical cannabis program, shows that,

"Results: Over 41% state that they use cannabis as a substitute for alcohol (n = 158), 36.1% use cannabis as a substitute for illicit substances (n = 137), and 67.8% use cannabis as a substitute for prescription drugs (n = 259). The three main reasons cited for cannabis-related substitution are “less withdrawal” (67.7%), “fewer side-effects” (60.4%), and “better symptom management” suggesting that many patients may have already identified cannabis as an effective and potentially safer adjunct or alternative to their prescription drug regimen."

Read More: http://informahealthcare.com/doi/abs/10.3109/16066359.2012.7...

http://www.ncbi.nlm.nih.gov/pubmed/24069004

Furthermore...

This is a great discussion regarding Cannabis Substitution and it is nearly a year old!

http://www.youtube.com/watch?feature=player_embedded&v=6Nt5Z...

3 main ways to non-psychoactive cannabis use

1. Find strain with insignificant amount of THC (such as Charlotte's Web, Harle TSU, etc)
2. Use topically (Prepare like you would to make medicated butter, but instead with food grade massage oil - like coconut oil - rub it over skin lesions and painful places)
3. Raw cannabis (for more info: www.medicaljane.com/cannabis-the-foundation-of-health/)

Some more articles on medical cannabis here:
http://www.nccpn.org/index.php?option=com_content&view=categ...

Good info!

I really wish I had made more clear that when I said "raw cannabis", I simply meant the flower by all by itself. That seemed to have gotten confused. My thinking was, once you mix it with an oil, it's no longer raw. I didn't intend to make it seem like raw plant material was useless. In fact, I think the raw material mixed with oil WITHOUT heating is more beneficial than after heating. But I do prefer the relaxing psychoactive effects too.

"Tu ne cede malis, sed contra audentior ito."

Have you heard of using soy lecithin powder to emulsify the oil?

Or is that an outdated technique?

Don't feed the pandas. Ever.

Original poster

you have a job waiting for you in this industry, hell with a job you can be a boss. The edible, ingestible market of this product is going to be huge, just don't sell out to Budweiser, Coca Cola or Pepsi and hold tight and start your own. I can feel your passion and with how precise you are, it seems you will be able to make different levels of effects from the medicine and different types of medicine in the ingestible market. You really need to look into this as I believe this market is going to be one of the biggest ones. You will be against big money, so I would suggest you start finding some investors who will respect and appreciate your knowledge and use it for good as well as for profit, not just for profit. This is an amazing post I wish I could give it 10 million up votes. We are gonna need smart libertarians to get on the bandwagon with this new emerging industry, and we need to make sure we use our gains to promote freedom and health, true health not just symptom stoppers. Awesome post, love it, a little confused but I get it. Controlling levels of effects is going to be the key to it all as everyone's sensitivity to this medicine will vary. You are on the right path. Nice job.

Those who expect to reap the blessings of freedom must. like men, undergo the fatigue of supporting it.-Thomas Paine

The R3volution requires action, not observation!!!!

It's a tough industry to crack

Big money is already here and growers are being led to bondage through there investors. They are running the small guys out of town, and soon the caregiver crackdown- keep your plant numbers in order and don't do anything stupid.

If there is a will there is a way pete. Keeping doing your great work on moving information about this spectacular plant.

In the beginning of a change the patriot is a scarce man, and brave, and hated and scorned. When his cause succeeds, the timid join him, for then it costs nothing to be a patriot.

Thanks!

.

"Tu ne cede malis, sed contra audentior ito."

I have not heard about lecithin.

I'm unsure, I guess the things to look for are, does the lecithin dissolve the cannabinoids, and does the lecithin absorb through the gastrointestinal tract easily.

Given the structure of a lecithin molecule on Wikipedia, I doubt it absorbs as readily as saturated fatty acids, but I really have no idea.

"Tu ne cede malis, sed contra audentior ito."

When I make my liposomal

When I make my liposomal vitamin c, I use sunflower seed lecithin. Just wondering if powdered cannabis can be made to absorb directly into the bloodstream through the same process as making the liposomal vitamin c, only replacing the vitamin C powder with cannabis powder? If cannabis is similiar in chemistry to an acidic substance, maybe so? Perhaps someone with the wherewithal to try it, can check this out. Where I reside, no chance. I do know that trying to emulsify oil via liposomal means fails right off! I tried it with coconut oil, and just got a gooey mess.

All oils are acidic. Coconut oil is solid at room temp,

Indicating that the fatty acid chains are longer. Lighter oils like sunflower or hemp have less viscosity, or friction in liquid, especially after the glycerin is removed through transesterification. Click the bodiesel link in my profile for more information.

Don't feed the pandas. Ever.

I read it years ago in a Freddie Freaker (?) comic...

It's an emulsifier which helps the oil bond with water when making brownies - similar to how soap is made.

Don't feed the pandas. Ever.

Ya' mean Fabulous Furry Freak Brothers? :)

Freak Brothers 2 photo brain.jpg

Actually, it was Fat Freddy's Cat I liked.
Fat Freddys Cat photo boohfatFreddyscat.gif

When we try to pick out anything by itself, we find it hitched to everything else in the Universe.
~ John Muir

Those are the guys.

Thanks!

Don't feed the pandas. Ever.

"P.S. I must express my disappointment in the cannabis market..

in Colorado. The state has instituted such ridiculous taxes and are further trying to regulate it so much it pisses me off."

No doubt, the State will drive a majority of the consumer base back to Black.

In my opinion, this is good for the Cannabis Community on many fronts:

1. the growers don't get raped financially and forced to co-op with a Commercial-sized entity just to make a profit (In WA, the Liquor Control Board has suggested that there be a 15% tax on each phase of the grow (Seedling, veg, flower)) I'm not sure if that part of the law was passed but I'll look into it.

2. the consumers won't go broke. As of today, the cheapest price I've seen for an ounce is $180, although WA's average is around $200-$220.

3. no limits on THC content (good for people who use it medicinally, considering they need a stronger dose)

Epic post, Pete. If you live in WA, we'll have to have some coffee and a blunt, Sir.

If you don't know your rights, you don't have any.

Thanks!

There will be benefits to the cannabis industry in having to work through such arbitrary problems. After this, it will be an extremely strong industry.

Plus, with the black market still in effect, there should still be good freedom if sought after.

Thanks for the compliments. Yeah a blunt and coffee would be cool, or, we could drink coffee, cream and cannabis oil... And then smoke a blunt too. Haha.

"Tu ne cede malis, sed contra audentior ito."

Lol well I still need

to drive home, Sir ;)

If you don't know your rights, you don't have any.

What if I want the medical benefits without the mind altering?

How would you take mj to get the benefits without the mind altering effects?

I would appreciate some kind of insight :)

Mind "altering"? You mean

Mind "altering"? You mean like the "mind alterinig" you would get from any pharmaceutical? I'm not sure they call it "mind altering" but they do label them with something.

THC is the "mind altering substance" you refer to and it helps a great deal with pain and other ailments.

Why don't you try meditation? Accupunture? Cannabis may not be appreciated by 100% of the world. Maybe only 90%

The world is my country, all mankind are my brethren, and to do good things is my religion. Thomas Paine, Godfather of the American Revolution

No, I mean the mind altering I would get from MJ

What was you purpose for replying to my comment?
You didn't answer my sincere questions. And you filled your rant with random quotation marks.

I have no idea who you were quoting when you said "mind altering substance". Who are you quoting? And what is your purpose for putting quotation mars around "mind altering" so many times.

You may not be aware of this but THC can have a psychoactive effect.
I don't enjoy that effect, but I would love to get any potential health benefits available.

Maybe you could learn the common use of "quotation marks" so that when you "write" your reader can "understand" your "intentions".

Or you could be a helpful fellow club member and point me in the right direction...maybe?

Good question.

If you don't want the psychoactive effects then you don't want to heat it. Keep the cannabis under 100 degrees F (that's a very low estimate, and it probably needs to be closer to 200 degrees F to decarboxylate THCA into THC). Also, use fresh product, and store in a cool, dark area because time and light can cause the THCA to turn into THC as well.

However, you will want to dissolve the cannabinoids in some sort of medium like fatty acids. Otherwise, the hydrophobic properties of the medical molecules will prevent it from absorbing into your body.

"Tu ne cede malis, sed contra audentior ito."

From personal experience...

I have a couple of friends who have been smoking MJ daily for maybe 40 years and as far as I can tell, it has adversely affected their brains. That's from my observation; there is a MJ "laugh" that is discernible as well as brain power not all there.