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B12 deficiency: A silent epidemic

What do all of these diseases have in common?

Alzheimer’s, dementia, cognitive decline and memory loss (collectively referred to as “aging”)
Multiple sclerosis (MS) and other neurological disorders
Mental illness (depression, anxiety, bipolar disorder, psychosis)
Cardiovascular disease
Learning or developmental disorders in kids
Autism spectrum disorder
Autoimmune disease and immune dysregulation
Male and female infertility

Answer: they can all mimic the signs and symptoms of vitamin B12 deficiency.

B12 deficiency: an invisible epidemic

B12 deficiency isn’t a bizarre, mysterious disease. It’s written about in every medical textbook and its causes and effects are well-established in the scientific literature.

However, B12 deficiency is far more common than most health care practitioners and the general public realize

For more - http://chriskresser.com/b12-deficiency-a-silent-epidemic-wit...

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deacon's picture

Info overload

A bump for later then? ok...will do
another reminder?

If we deny truth before your very eyes,then the rest of what we have to say,is of little consequence

SteveMT's picture

It's a big molecule that is poorly absorbed.

To better absorb B12, we make "intrinsic factor" in our gut. Without that protein, B12 will only be minimally taken in and injections become necessary.

Vitamin D deficiency is another silent epidemic. Vit D is 100X more active in our bodies than thyroid hormone. It's easily fixed by taking 5-10,000 I.U. D3/day.

I have pages and pages of info on this topic

I inject cyan though I wish I could methyl. I also take (overload for repair) methyl sublinguals. When I got started with this whole thingy (emergency gallbladder surgery, followed by double foot-drop/paralysis & mononeuritis multi-plex, then diabetes) I found a site that will take forever to glean from (17,XXX replies) but is important. I cannot supply you with original links, for the links I have in my research are now dead but a few point to here which looks to be the same content moved to a new place.

Some (more) reasons for B12 deficiency:
• colchicine (for gout)
• phenytoin (for seizures)
• metformin (fordiabetes)
• acid-reducing drugs (for ulcers, acid reflux)
• Oral contraceptive use: http://www.ncbi.nlm.nih.gov/pubmed/474643(p.s., this study says supplementing B12 does not help for this since it is the B12 BINDING CAPACITY that is reduced) - (fyi, this is probably NOT identical hormone replacement...most prior studies did not distinguish pharmaceutical hormone replacement, which is patently NOT estrogen, from actual estrogen)

Inability to convert B12 to active forms:
• genetic mutations creating ineffective enzymes for converting cyanocobalamin or hydroxycobalamin to the active forms (which are methylcobalamin and adenosylcobalamin)
• nutritional deficienc(ies) creating inadequate enzymes for converting B12 to active forms
Nutritional deficienc(ies) causing B12 deficiency may themselves be caused by:
• vegan diet w/o B12 supplementation
• alcoholism
• anorexia
• improper diet

Absorption problems:
• lack of intrinsic factor
• atopic gastritis
• celiac/sprue
• tapeworm
• Crohn's disease
• stomach surgery
• overgrowth of bacteria in the gastrointestinal tract
• diseases of the pancreas

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

reedr3v's picture

You've done an impressive amount of research

I hope your initial complex medical issues have been helped. Did you resolve the foot drop problem? My daughter was hospitalized for months after being hit by a car and also suffered foot drop; physical therapy has been only partially helpful. I'll have her B12 levels checked. After a 4th surgery recently her red blood count was low and she's taking oral folic acid.
She suffered severe traumatic injury that affected a left side communication area of her brain, and neuron damage causing semi-paralysis of the right arm and leg, so we are promoting neuroplasticity regrowth/redirection of function primarily with good diet (paleo)and physical/aphasia therapy. I've been cautious with fish oil, and vit. e due to blood thinning concerns.
Did you check out the Kresser articles and their replies linked in this thread? So much great information.

I had a big thingy written here

and then a cat walked across the keyboard and shut down firefox and disappeared it all. Argh. So this coming reply may be a bit garbled.

First off, sorry to hear about your daughter's troubles. As long as the nerve is not cut completely in half, there's hope. I hope you won't mind I've added you and her to my prayer list. Hugs.

Yes the foot drop went away after about 6 months, since then I've had another sort of "Saturday Night Palsy" and nerves always firing wrong, an exacerbation about every other month varying from my legs, my eyes, my jaw, etc etc. I for sure am not "sure-footed" worth a hoot and am as clumsy as Chevy Chase portraying Gerald Ford and wind up injuring myself. :(

Have y'all tried one of those thingies like tens machine but way stronger to "make her muscles respond"? I have one and it's the only thing that would lift my feet off the floor when I had foot drop.

Also, don't forget that each surgery a person has, if they lean b-12 deficient, should always as routine get a bumped up round of b-12 shots before and after. Anesthesia depletes b-12.

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

reedr3v's picture

Thank you SC,

We have a little TENS-type machine but have used it irregularly; it seems to be advertised as primarily for pain management rather than nerve stimulation of movement. But since you found a more powerful version helpful for muscle response, can you tell me the brand name?

Also I don't recall mention in this thread of the importance of magnesium for muscle relaxation and calming nerve disorders. We find it helpful, with no deleterious side effects. Magnesium Citrate, topical magnesium oil, even Epsom Salt baths; Oh, and very dark chocolate : )

I actually have it right here beside me :)


Neuromuscular Electrical Stimulation (NMES) is a non-invasive, non-addictive means of muscle rehabilitation after injury, surgery or disease. Patients with a wide range of orthopedic and neurologic diagnoses can benefit from NMES, which applies customized electrical stimulus to cause a muscle to contract.

Absolutely I use magnesium oil, have you made any yet?

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

reedr3v's picture

Thanks for the name; I'll research further

And you make your own magnesium oil! So cool, I just Googled how to do that; excellent tip.
We are in Bangkok because quality therapy and medical treatment here is much less expensive, and a family member lives locally and is very supportive. BUT the Thai FDA is even more restrictive than in the U.S. for supplements!
It's hard to obtain good supplements here; health stores cannot carry them, and the pharmacies have poor quality; magnesium oxide instead of citrate or other better forms. I've been told places like Amazon won't ship supplements here. But maybe I'll be able to find magnesium flakes, since they're not for oral supplementation.


I found some links for you but don't know if you can order from them for Thailand residency either. ???

Swanson - Mag Flakes
iherb - Mag Flakes
Or lastly this (which may be irritating to skin) The jury has not returned a verdict exactly on mag citrate for topical use, however since mag citrate may be the best internal form, and since our skin is our largest organ, having the ability to even uptake the chems from perfume and such, I'd say mag citrate oil recipe should be fine but have not tried it. It could leave a powdery residue but the flake oil leaves a sort of sticky to it that's odd also but better than hurting.
iherb - Mag Citrate

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

reedr3v's picture

Thank you for this,

and for all the good you do in the world!


to you and yours reedr3v!

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

1,000mcg (16,667%) per day

1,000mcg (16,667%) per day in my Beyond Tangy Tangerine 2.0! Love it!

It helped me

I have a neuropathy issue in my lower legs and my ankle & feet area. Circulation problems. My 80 something pool shooting buddies told me about Vitamin B'S and B12 they take for circulation problems. My nurse girlfriend confirmed it's value and I bought a bottle of B complex with B12 or something from the grocery store. And I kid you not, Within a week my tingling sensations from the circulation issues were much less. Now 2 weeks later I have zero problems in my lower extremities except when I sit at the desk for long periods of time. Appears to be very helpful in that area for me.

I am not a doctor, but I play one on teevee

This is what I personally "stack" with cyan injections

(for serious nerve damage)
Jarrow Formulas, Methyl B-12, Cherry Flavor Lozenges

Country Life, Gluten Free, Active B12 Dibencozide Lozenges

Jarrow Formulas, B-Right

Solgar, Folate Metafolin Folic Acid

Now Foods, Gamma E Complex, Advanced

Potassium, your choice of brand and form - this is insurance against hypokalemia triggered by sudden healing and potentially fatal - if you have blood tests, potassium is usually checked, midrange, around 4.5 is good. Some people will have problems at bottom of "normal" range, 3.5-4.0.

Omega3 fishoils - essential for myelin sheathing for the nerves, many brands will do, 2-6+ capsules per day, I buy it at Costco, house brand. This is available in many supermarkets.

Zinc - 50 mg
Calcium/magnesium supplement (for me mag must be overloaded)
D - 3000-5000 IU total (10,000 in winter)
A&D from fish oil, 10,000-(400-800-1000) Vitamin A should be 10,000, D might be any of 3 numbers with additional D to be taken

Possibly Critical Cofactors, add after initial stages, any number of these in any combination may be required for maximum effectiveness:
SAM-e - 200-400mg/day, makes methylb12 more effective, possibly much more effective, increases energy, improves mood

TMG - enhances SAM-e, methylb12, l-carnitine

L-carnitine fumarate (acetyl might work better for some), works with adenosylb12, lack can completely prevent effectiveness of adenosylb12, increases energy, aerobic endurance, improves mood

Alpha Lipoic Acid - enhances l-carnitine and adenosylb12

D-Ribose - enhances adenosylb12, l-carnitine, alpha lipoic acid, improves exercise recovery and energy

Additional possibly helpful cofactors
Chromium GTF

Glutathione and glutathione precursors such as NAC and glutamine, undenatured whey. The glutathione induces immediate active b12 deficiencies, apparently by converting active methylb12 to inactive glutathionylb12 and rapidly excreting it.

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

deacon's picture


Thank you for the reminder,with everything going on and downhill,i had forgotten this topic and post.

If we deny truth before your very eyes,then the rest of what we have to say,is of little consequence

Glad to help

let me know if I can answer any questions. The info is quite inundating.

Freedom is not: doing everything you want to.
Freedom is: not having to do what you don't want to do.
~ Joyce Meyer

I know a doctor who fights it

like a champ for one of my loved ones. He doesn't even let bloodwork that shows improvement in B-12 levels distract him from the fight. He says that elevated homocysteine levels but better B-12 might mean the body is increasing its B-12 levels but not USING it enough. He insists on not just B-12 supplements, but, especially if the MTHFR gene is suspected, on METHYLATED B-12 supplements, methyl folate supplements, B6, AND TMG.

This doctor's forward thinking approach has saved a number of my family from some issues mainstream doctors wouldn't have had an explanation for, much less a plan to fight it.

Defend Liberty!


You can increase B-12 absorption, 160% by raising your MBP (mannan binding proteins)It will also help recognize inflammatory proteins (homocysteine and C reactive protein)levels and decrease those too.

I was blown away by the

I was blown away by the comments on this link. I had no idea B12 deficiency was so common, and at all age ranges.