Comment: In the UCLA study, there was a consistent trend

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In the UCLA study, there was a consistent trend

albeit short of statistical significance -- toward lower cancer risk among even the heaviest marijuana smokers. This was a surprise to some, given that marijuana smoke contains many of the same carcinogenic compounds as tobacco smoke.
The researchers wrote:
"Although purely speculative, it is possible that such inverse associations may reflect a protective effect of marijuana. There is recent evidence from cell culture systems and animal models that 9-tetrahydrocannabinol, the principal psychoactive ingredient in marijuana, and other cannabinoids may inhibit the growth of some tumors by modulating key signaling pathways leading to growth arrest and cell death, as well as by inhibiting tumor angiogenesis.

These antitumoral associations have been observed for several types of malignancies including brain, prostate, thyroid, lung, and breast."
In an October 2003 review in the journal Nature Reviews: Cancer, Guzman detailed the extensive body of test-tube and animal research showing that cannabinoids inhibit tumors of the lung, uterus, skin, breast, prostate and brain (including gliomas, the type of tumor that killed Sen. Edward Kennedy). He also noted: "Cannabinoids have favorable drug-safety profiles and do not produce the generalized toxic effects of conventional chemotherapies. Cannabinoids are selective antitumor compounds, as they can kill tumor cells without affecting their non-transformed counterparts."

"Such selectivity is exactly what you want in an anticancer drug. The reason chemotherapy can be so awful is that most chemo drugs aren't selective enough; they kill cancer cells, but are also toxic to healthy cells, leading to vomiting, hair loss and other miseries.

http://www.cannabisculture.com/v2/content/2010/01/26/Marijua...

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