Comment: The vaccines "work," but not very well.

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SteveMT's picture

The vaccines "work," but not very well.

Findings
We screened 5707 articles and identified 31 eligible studies (17 randomized controlled trials and 14 observational studies). Efficacy of TIV (trivalent inactivated vaccine) was shown in eight (67%) of the 12 seasons analyzed in ten randomized controlled trials (pooled efficacy 59% [95% CI 51—67] in adults aged 18—65 years). No such trials met inclusion criteria for children aged 2—17 years or adults aged 65 years or older. Efficacy of LAIV was shown in nine (75%) of the 12 seasons analyzed in ten randomized controlled trials (pooled efficacy 83% [69—91]) in children aged 6 months to 7 years. No such trials met inclusion criteria for children aged 8—17 years. Vaccine effectiveness was variable for seasonal influenza: six (35%) of 17 analyses in nine studies showed significant protection against medically attended influenza in the outpatient or inpatient setting. Median monovalent pandemic H1N1 vaccine effectiveness in five observational studies was 69% (range 60—93).
Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis - Published Online: 26 October 2011
http://www.thelancet.com/journals/laninf/article/PIIS1473-30...