He's certainly not one of the more dynamic or enthused speakers to hit the TED stage. He is the penultimate of droll, and his overall subject matter is far less than typical TED-sexy. Nonetheless, I find this TED talk to be the most fundamentally essential I've ever heard. Sheldrake waxes eloquently regarding important fallacies built deeply into our current foundational paradigm. I butt heads even here at the DP when regarding such flaws.
He typically speaks on two unrelated issues. One is the bulk of what he's known for lately, commentary on the current state of science in general. Two is his own study of what he calls "morphic fields".
another hour of Sheldrake lecture...
http://www.youtube.com/watch?v=0waMBY3qEA4 part one
http://www.youtube.com/watch?v=VRKvvxku5So part two
an interesting interview...
http://www.youtube.com/watch?v=AFSsJHI5Zds about 20 minutes