first I was a little skeptical of some of the results being claimed. I figured it did a few things like alleviate nausea and increase appetite, but I had no idea until I saw some things first hand.
Here are just a few abstracts of studies that are related to certain cancers. There is so much more. I don't think I've ever been as intrigued about a subject as I am about this. This could be some sort of fountain of youth. (and I don't use those words lightly)
New research out of Spain suggests that THC (the active ingredient in marijuana) appears to prompt the death of brain cancer cells. The finding is based on work with mice designed to carry human cancer tumors, as well as from an analysis of THC's impact on tumor cells extracted from two patients coping with a highly aggressive form of brain cancer. This extremely significant discovery is to be noted for its medical application, particularly because the THC appears "to kill cancer cells, while it does not affect normal cells." The findings were published in the April issue of The Journal of Clinical Investigation. Another recent finding, published in the journal Molecular Cancer Therapeutics, has discovered that combining the two most common cannabinoid compounds in cannabis may boost the effectiveness of treatments to inhibit the growth of brain cancer cells and increase the number of brain cancer cells that die off.
Cannabis extracts shrink brain tumors and other cancers by blocking the growth of the blood vessels which feed them, suggests a new study. An active component of cannabis has previously been shown to improve brain tumors in rats. But now Manuel Guzmán at Complutense University, Spain, and colleagues have demonstrated how the cannabis extracts block a key chemical needed for tumors to sprout blood vessels - a process called angiogenesis. For the first time, the team has shown the cannabinoids impede this chemical in people with the most aggressive form of brain cancer - glioblastoma multiforme. "The cannabinoid inhibits the angiogenesis response - if a tumor doesn't do angiogenesis, it doesn't grow," she explains. "So if you can improve angiogenesis on one side and kill the tumor cells on the other side, you can try for a therapy for cancer."
The team tested the effects of delta-9-tetrahydrocannabinol in 30 mice. They found the cannabis extract inhibited the expression of several genes related to the production of a chemical called vascular endothelial growth factor (VEGF). VEGF is critical for angiogenesis, which allows tumors to grow a network of blood vessels to supply their growth. The cannabinoid significantly lowered the activity of VEGF in the mice and two human brain cancer patients, the study showed. The drug did this by increasing the activity of a fat molecule called ceramide, suggests the study, as adding a ceramide inhibitor stifled the ability of the cannabinoid to block VEGF. "We saw that the tumors [in mice] were smaller and a bit pallid," adds Blázquez. The paleness of the cancer reflected its lack of blood supply as a result of the treatment. In the human patients, she says: "It seems that it works."
A chemical compound that occurs naturally in the cannabis plant may prevent breast cancer from spreading, according to a study published in the journal of Molecular Cancer Therapeutics. Researchers found that a chemical called cannabidiol (CBD) affects the activity of a gene known as Id-1 in patients with hormone-independent breast cancer. In embryos, Id-1 is responsible for helping cells grow and spread, but is supposed to remain inactive in adults. In human adults, it is found only in metastatic cancer cells, or cancer cells that are spreading throughout the body. The chemical's major advantage, according to the researchers, is its non-toxicity, unlike treatments such as chemotherapy.
A compound found in cannabis has been found to stop breast cancer spreading throughout the body by US scientists. The California Pacific Medical Center Research Institute team are hopeful that cannabidiol or CBD could be a non-toxic alternative to chemotherapy. CBD works by blocking the activity of a gene called Id-1 which is believed to be responsible for the aggressive spread of cancer cells away from the original tumour site - a process called metastasis. Past work has shown CBD can block aggressive human brain cancers. The latest work found CBD appeared to have a similar effect on breast cancer cells in the lab.
Test tube studies sugget that THC and another cannabis-derived compound slow the spread of cervical cancer. The findings add to the fast-growing number of animal and cell-culture studies showing different and direct anticancer effects for cannabinoids, chemical compounds derived from cannabis.
A myriad of studies have proven many times over that cannabis is very helpful by being an antiemetic medicine in those who have undergone chemotherapy. Studies have confirmed the usefulness of THC in patients whose chemotherapy-induced nausea and vomiting is refractory to other standard antiemetics.
A new study out of Thailand demonstrates that THC can fight cholangiocarcinoma – cancer of the bile duct. This is a rare but deadly form of cancer, with only 30% of patients still alive after five years, according to the Cholangiocarcinoma Foundation. Based on these new lab results, the Thai researchers conclude, “THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.”
Preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing role in human colorectal cancer, scientists report in the Aug. 1 edition of the journal Cancer Research. CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for the cannabinoid group of signaling molecules. It now may serve as a new path for cancer prevention or treatment. Treating mice that had the CB1 receptor with an endocannabinoid agonist resulted in a decline in polyps ranging from 16.7% to 50%. The reduction was greater for larger polyps. CB1 thwarts survivin, a protein that protects cancer
Cannabinoids previously had been shown to kill cancer cells in lab experiments by inducing apoptosis - programmed cell death. The team confirmed the role of CB1 in apoptosis, showing that tumor cells with high CB1 expression were sensitive to apoptosis when treated by a cannabinoid agonist. Cell lines with silenced CB1 resisted cell death. A series of experiments showed that CB1 increases cancer cell death by stifling a protein called survivin. Survivin is overexpressed in nearly every human tumor but is barely detectable in normal tissue.
The New Drug Study Group in London discovered that THC, the active ingredient in cannabis, works to kill leukemia cells by affecting the gene, MKP3. In a study published in the February 2005 issue of Blood, Dr. Wai Man Liu and colleagues at St. Bartholomew's Hospital in London reported that THC-induced cell death in a panel of leukemia cells, including two AML cell lines. Liu and his team have begun to uncover the mechanism by which THC kills those cells and potentially promotes longer-term survival. In another study, US scientists who found out that exposure of leukaemia cells to CBD led to a reduction in cell viability and induction of apoptosis. In living animals CBD caused a reduction in number of leukaemia cells. The scientists noted that CBD "may be a novel and highly selective treatment for leukemia."
The active compound in cannabis (THC) can slow the growth of lung tumors and reduce the spread of the cancer in mice. In a study done recently, human lung cancer tumors grew less than half as fast in mice that received moderate doses of the compound. Ramesh Ganju at the Harvard Cancer Center in Boston, Massachusetts, US, and colleagues deposited human lung cancer cells under the skin of a dozen mice and allowed the tumors to grow in the animals for about two weeks. They then began giving half of these mice daily injections of about 250 micrograms of synthetic THC right next to the tumors for three weeks. A cannabis cigarette may contain as much as 150 milligrams of THC, indicating that even a microdose can have visible anti-cancer effects. Tumors in the control mice averaged about 0.6 grams in weight by the end of the five-week trial. By comparison, those in the mice that received THC weighed just 0.25 grams - 60% less.
THC and other cannabinoids induce apoptosis in murine tumors of immune origin, according to researchers at Virginia Commonwealth University in Richmond. In a series of in vitro experiments, Dr. Nagarkatti and her colleagues exposed murine lymphoma and mastocytoma cells to four cannabinoid receptor agonists. THC and two of the others significantly reduced cell viability and increased apoptosis. In vivo experiments confirmed the effect of THC. Ten days after mice were injected with lymphoma cells, cells collected from animals treated with the highest dose of THC showed 77.3% apoptosis. Two weeks of THC treatment cured 25% of lymphoma-bearing mice. The research group also demonstrated that three human leukemia and lymphoma cell lines expressed CB2 and not CB1. Three cannabinoids, including THC, induced apoptosis in these cell lines in vitro, and THC showed the same effect when cultured with cells from patients diagnosed with acute lymphoblastic leukemia.
A study found that cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumor biopsies at much higher levels than in normal pancreatic tissue. Studies conducted with MiaPaCa2 and Panc1 cell lines showed that cannabinoid administration induced apoptosis, increased ceramide levels, and up-regulated mRNA levels of the stress protein p8. Cannabinoids also reduced the growth of tumor cells in two animal models of pancreatic cancer. In addition, cannabinoid treatment inhibited the spreading of pancreatic tumor cells. Moreover, cannabinoid administration selectively increased apoptosis and TRB3 expression in pancreatic tumor cells but not in normal tissue.
A recent study showed that expression levels of both cannabinoid receptors, CB1 and CB2, are significantly higher in CA-human papillomavirus-10 (virally transformed cells derived from adenocarcinoma of human prostate tissue), and other human prostate cells than in human prostate epithelial and virally transformed cells derived from normal human prostate tissue. It was observed that there was an induction of apoptosis, a decrease in protein and mRNA expression of androgen receptor, a decrease in intracellular protein and mRNA expression of prostate-specific antigen, a decrease in secreted prostate-specific antigen levels, and decrease in protein expression of proliferation cell nuclear antigen and vascular endothelial growth factor. The results suggest that cannabis can be an effective treatment for prostate cancer.
Further research has found that chemicals in the cannabis plant have been found to stop prostate cancer cells from growing in the laboratory. After working initially with human cancer cell lines, Ines Diaz-Laviada and colleagues from the University of Alcala in Madrid also tested one compound on mice and discovered it produced a significant reduction in tumor growth. The cannabinoids tested by the Spanish team are thought to work against prostate cancer because they block a receptor, or molecular doorway, on the surface of tumour cells. This stops them from dividing. In effect, the cancer cell receptors can recognize and "talk to" chemicals found in cannabis.
Want DP delivered to your inbox daily? Subscribe here:
Content of posts and comments on the Daily Paul represent the opinions of the original posters, and are not endorsed, approved, or otherwise representative of the opinions o