Comment: Magnesium: An Epidemic Deficiency in the US!

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Magnesium: An Epidemic Deficiency in the US!

Adequate Mg intake may not reduce "bus accidents", but it may very well prevent metabolic syndrome.

Empirical evidence has been growing for decades that the majority of Americans do not get the official recommended (minimum) daily allowance (RDA) for magnesium. For example, one study found that 68% of Americans do not consume the recommended RDA of magnesium and 19% do not even consume half. Moreover, those with intakes below the RDA were more likely to have elevated CRP, a known risk factor for cardiovascular disease.*

Mg2+ is an essential activator of >300 enzymes (e.g. RNA polymerases, ATPases, protein kinases, phosphatases, glutathione synthase, and carboxylases), and is involved in regulating ion transport and cation balance.

Because it binds with water molecules 3–4 orders of magnitude more tightly than do other cations, Mg2+ often interacts with other ions and molecules while still maintaining its hydration sphere. As a result, Mg2+ binds relatively weakly to the negatively charged groups in the cell membrane, so excess cations such as H+, Ca2+, and Al3+ present under acidic conditions can inhibit Mg2+ transport and uptake across cell membranes.

*J Am Coll Nutr. 2005 24(3):166-71.

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