Even though there would have undoubtably been some differences (how substantial they would be is another matter), the office of President is only one cog in the machinery that determines the course of our nation. Considering the remaining sludge that is pervasive in positions of power and influence, even had Ron Paul been elected, getting much real "change" would have been difficult at best and impossible at worst.
The last "good" President (Ronald Reagan) in many ways watered some of the nastiest seeds of destruction for the republic (for example perpetual deficit spending, expanded imperialism, etc).
Getting past the notion that the President should make a huge difference is part of the solution to the problem (part of a wider pull away from centralized power).
"Sometimes it is said that man cannot be trusted with the government of himself. Can he, then, be trusted with the government of others? Or have we found angels in the forms of kings to govern him?" -Thomas Jefferson
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